Synthesis of Chiral Fluorinated Propargylamines via Chemoselective Biomimetic Hydrogenation.
نویسندگان
چکیده
A highly enantioselective synthesis of chiral fluorinated propargylamines was developed through phosphoric acid and ruthenium-catalyzed chemoselective biomimetic hydrogenation of the carbon-nitrogen double bond of fluorinated alkynyl ketimines in the presence of a carbon-carbon triple bond. This reaction features high chemoselectivity and slow background reaction. In addition, selective transformations of the chiral fluorinated propargylamines were also reported.
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ورودعنوان ژورنال:
- Organic letters
دوره 18 18 شماره
صفحات -
تاریخ انتشار 2016